Step one terminate nonopioid analgesics (eg, n-(4-hydroxyphenyl)acetamide or nonsteroidal antiinflammatory stupefy ), gait two unite milder opioids (eg, codeine, hydrocodone, oxycodone, tramadol, vowel recreational drug), and behavior three incorporates stronger opioids (eg, parenteral morphine, dihydromorphinone, fentanyl). Opioids dissent with regard to pharmacokinetic sign such as partial-vivacity, and lively v. nonactive metabolites.

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