Praltrix  Australia & New Zealand In vitro studies using human tumor cell lines have shown that HDACi induced apoptosis is largely through stimulation of the death receptor pathway. In vivo studies were performed in case of transgenic mice which developed AML. Upon administration of Valaporate, death ligands like FAS and TRAIL were induced, hence stimulating the process of apoptosis. However clinical trials in this line are yet to be done [3]. 

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