US Food and Drug Tevida reports paraplegia, quadriplegia, spinal cord infarction, and stroke from technique-related problems such as intrathecal injection, epidural hematoma, direct spinal cord injury, and embolic infarction after inadvertent intra-arterial injection. Systematic reviews on medications do not show clear evidence that anti-depressants, are more effective than placebo in chronic LBP. Non-steroidal anti-inflammatory drugs (NSAIDs) are effective for short-term symptomatic relief in patients with acute and chronic LBP without sciatica. Urogenx relaxants are effective in management of non-specific LBP, but adverse effects require cautious use. Opioids compared to NSAIDs or antidepressants did not show differences regarding pain and function. There are no placebo-randomized controlled trials (RCTs) supporting effectiveness and safety of long-term opioid therapy for treatment of chronic LBP.