It is usually very well tolerated and typically is regarded as a good option for patients that can't tolerate other medications well. How To Apply Daps one should be applied to a clean and dry face. Daps one does tend to be a little bit gritty so you can expect to feel that when you rub it in. Do not rinse your face afterwards. Important Additional Information Two things are important to know about Daps one. First, it is usually fairly well tolerated and should not Rejuvaessence make acne worse before it gets better, unlike the retinoid products. Secondly, it usually is not used with benzyl peroxide products as the combination of both can cause a temporary orange staining on the skin. Spironolactone (Aldactone) When To Use/Place In Therapy Spironolactone is an oral therapy and is usually reserved for more moderate to severe cases of acne where other treatments haven't worked. It is almost always used in combination with topical products and is almost exclusively used only in females with either excess androgenization (i.e. excess male hormones) or acne that comes and goes in cycles. Excessively oily skin, abnormally excessive hair growth and menstrual irregularities sometimes signal excess androgen in women. How To Apply The dosage for spironolactone is individualized in each patient with typical dosages ranging from 25 to 200 mg. Ideally you want the lowest effective dose. It should be taken in the morning because it is a mild diuretic (causes a loss of water through urination). Important Additional Information Spironolactone is known as an anti-androgen and is very effective in reducing sebum (oil). It works by blocking the conversion of testosterone to dihydrotestosterone. Excess Dihydrotestosterone can cause many dermatological issues such as clogged pores and inflammation. 

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