Leptigen :- Or hydroxycitric acid (HCA), it was concluded that the various studies supported its safety and also demonstrated a wide margin of safety for human consumption. The animal and clinical toxicology studies have also shown that HCA is generally safe and is classified as NOAEL (No Leptigen Observable Adverse Effect Level) up to 1240 mg/kg/day. In addition, by virtue of the fact that the HCA extract has been widely used as an anti-obesity herbal supplement for decades around the world without report of birth defect or reproductive problem suggests that HCA is unlikely to .