Endovex Of testosterone deficiency symptoms include depression, fatigue, male issues, irritability, loss of facial/body hair, thinning and/or wrinkling of skin, weight gain, and the weakening of both bone and muscle tissue. Eventually, imbalances of testosterone can set the stage for the development of more serious disease. Low testosterone levels can also disrupt the body's blood sugar metabolism, leading to obesity and diabetes. Chronic deficiencies may also promote the early onset of osteoporosis and heart disease.Suddenly, pharmaceutical patches are available for any condition: