Superior Test X Creatine supplements are popular in the muscle building community. However, they must be treated with caution. Make sure not to use these types of supplements at all if you have any type of kidney problem. Additional known complications include muscle cramps and compartment syndrome. Creatine supplements have even been linked with heart arrhythmia. People who are still growing are at the greatest risk of potential harm. These supplements should only be taken in the correct manner.