Are in various contacts and how that impacts on these two tightly related tissues and notice and I put always in print to seize I was almost tempted to put rarely inhere arm in context I think you'll see why by the end my presentation I want to acknowledge a prank the people who’ve done the hard work behind the data you'll see listed their current and former members have my laboratory I start those who made the largest contributions to the data you'll see included herein week Livery tightly without engineering callings in mechanical and biomedical engineering and you'll see several listed there who contributed heavily to our measures have bone function arm also good morning Georgia State is a frequent Gmax collaborator and actually did importantly to number the studies and we acknowledge our support of course from an SPI Ryan nasal are in a lot of these tissues arcade-entered studies so the removal mechanical loading of course is just another way to describe are the importance above physical activity in loading on bone and muscle in this case a bone mass it's a very potent down regulator arm and you can see much more rapid change in this usually slow changing tissue with the arm disuse what you see pictured here our data that derived from on a study by Adrian Leblanc focusing on cosmonauts exposed to you arm conditions weightlessness for anywhere from four to fourteen months so these changes in on Dexter measures a bone mineral density are expressed in a percent change per month are so normalize per month and you'll notice that an there's very little change in the arms but and change .

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