Another risk associated with intensive use is to develop liver problems. Again, this is not a typical result of short-term use and is usually XLR8 Plus seen only when using overdoses. In such cases, it has been shown to increase certain enzymes known to cause liver damage. When taken at appropriate levels of healthy individuals, but the risk of side effects is minimal. If you have a history of liver problems or taking medications or supplements that are known to be harsh on the liver again, you should talk to your doctor before using this compound.