In exploratory studies, it has shown prolonged release melatonin improved sleep quality in patients with schizophrenia , as well as in patients with major depressive disorder.   has shown promise in the treatment of sleep-wake cycle disorders in children with underlying difficulties nervous growth.   may also reduce the disruption Marz Sleep Sprays of the biological clock and seasonal affective disorder (SAD).   In addition, as the addendum to treat high blood pressure, prolonged release improvement of melatonin in the blood pressure control in patients with high nocturnal blood pressure as shown in the double-placebo study randomized blind controlled.